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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caseins
supplement:
Epigallocatechin Gallate
Research Papers that Mention the Interaction
“(−)Epigallocatechin‐3‐gallate EGCG ), the main flavanol in green tea and known to inhibit inflammation and tumor invasion, exerts dose‐dependent inhibition of degradation of gelatin (IC50<20 μM) and casein , which is directly triggered by PR‐3.”
Proteinase‐3 directly activates MMP‐2 and degrades gelatin and Matrigel; differential inhibition by (−)epigallocatechin‐3‐gallate“ Casein addition also decreased bitterness intensity of the EGCG solution.”
“We also tested whether bovine milk casein , a food analog for salivary proteins that may suppress bitterness, would decrease bitterness intensity of the EGCG solution and mitigate effects of the intervention.”
Repeated exposure to epigallocatechin gallate solution or water alters bitterness intensity and salivary protein profile“Subsequently, these findings were correlated with the interactions between EGCG and casein.”
“The in vitro release demonstrated that casein, especially glycosylated casein, could effectively protect EGCG from degradation in alkaline pH and displayed a slow and sustained release in intestinal fluid, which may be attributed to the inhibiting effects of casein binding on the motion freedom of EGCG.”
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