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“Combined exposure of Mn and Cu also produced a greater elevation in the levels of dopamine (DA) and norepinephrine (NE) and a depression of 5-hydroxytryptamine (5-HT) in the brain of animals fed with a 10% casein diet compared to the animals receiving the 21% casein diet.”
“Thus the animals receiving the 10% casein diet appear to be more vulnerable to the neurotoxic effects of a combined exposure to manganese and copper.”