Possible Interaction: Caseins and Colchicine

“Notwithstanding the presumptions of the pathogenesis of amyloidosis and the capacity of colchicine to inhibit amyloid synthesis in rats treated with casein , the form in question derived little benefit from the association of colchicine (0.5 mg t.i.d.)”

“Treatment with cytochalasin D or colchicine for 24 h inhibits the accumulation of α‐casein , transferrin, and α‐lactalbumin without significant effect on general protein synthesis.”

“Administration of colchicine , which prevents casein-induced amyloidosis, suppressed the SAP response to casein in CBA mice.”

“When mice were treated with colchicine during the first 7 days of an amyloid induction regimen or when colchicine was given to the donor mice in a transfer model, the amyloidogenic stimulus of casein was blocked completely.”

“ Colchicine was shown to inhibit the attraction of neutrophils to casein and to a bacterial chemotactic factor at concentrations as low as 10(-7) M. Experiments in which the absolute concentrations and the concentration gradients of the chemotactic agent were varied, revealed that colchicine inhibited chemokinesis rather than chemotaxis.”

“ Colchicine was shown to inhibit the attraction of neutrophils to casein and to a bacterial chemotactic factor at concentrations as low as 10‐7 M. Experiments in which the absolute concentrations and the concentration gradients of the chemotactic agent were varied, revealed that colchicine inhibited Chemokinesis rather than chemotaxis.”