Possible Interaction: Carvedilol and Calcium Supplement

“ Carvedilol at concentrations between 1 and 30 μM increased [ Ca 2+]i in a concentration-dependent manner.”

“ Carvedilol significantly inhibited the amplitude of the calcium transient in a concentration-dependent manner.”

“ Carvedilol inhibited mitochondrial swelling with calcium plus phosphate and with calcium plus t-butylhydroperoxide, but not with calcium plus carboxyatractyloside.”

“ Carvedilol inhibited the oxidation of thiol groups with calcium plus phosphate (p<0.01) and with calcium plus t-butylhydroperoxide (p<0.05), but not with calcium plus carboxyatractyloside—in opposition to the full protection afforded by cyclosporin-A when using calcium and carboxyatractyloside.”

“In addition, carvedilol (10(-7) to 3 x 10(-5) M) suppressed the contraction produced by Bay K 8644, a Ca2+ channel agonist.”

“The effects of adrenaline on astrocytes were less dependent on adrenoreceptors: the antagonist carvedilol had only moderate effect on the calcium signal and the agonist of adrenoreceptors methoxamine induced a signal only in small proportion of the cells.”

“The … of carvedilol decreased, depending on the stimulus used, in the following rank order of potency (in parentheses the respective mean … of carvedilol and propranolol are given in w mol/l): PMA (19 and 34) > thrombin (55 and 77) > Ca 2 + -ionophore A23187 (58 and …) > epinephrine (86 and 118).”