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Last Updated: a year ago

Possible Interaction: Carrageenan and Nitric Oxide



Research Papers that Mention the Interaction

λ-carrageenan (1% w/v in 0.2 ml sterile saline) determined an intense recruitment of …) synthase and cyclooxygenase-2, thus increasing the generation of harmful autacoids such as NO and pro-inflammatory prostaglandins, PgE₂ and 6-ketoPgF(1α), increased … the local generation of IL-1β and TNF-α.
Current pharmaceutical design  •  2014  |  View Paper
Conclusion:The results of … study suggest that NO activates COX-1 in … early phase of carrageenan and up-regulates COX-2 expression in the late phase in the skin, resulting in production of … and PGI2 at the site of inflammation, which would contribute to exacerbation of the inflammatory process.
Results Carrageenan injection resulted in increases in the concentrations of NO , PGE2, and PGI2, and these increases were completely suppressed by NG-monomethyl-l-arginine acetate.
Anesthesiology  •  2004  |  View Paper
The results of the current study show that carrageenan induces peripheral release of NO , the production of which is mediated by nNOS in the early phase and by both nNOS and iNOS in the late phase of carrageenan-induced inflammation.
Brain Research  •  2001  |  View Paper
Obtained results suggest that nitric oxide derived from inducible nitric oxide synthase play an inhibitory role in carrageenan produced hyperalgesia in rat.
Life sciences  •  2000  |  View Paper
The peak values at 12 hr after the LPS challenge were dependent on the dose of CAR with 1 to 5 mg, although the injection with 10 mg of CAR was adversely inhibited NO production compared with 5 mg of CAR.
Life sciences  •  1995  |  View Paper
It has also been reported that nitric oxide is positively regulated by carrageenan and negatively regulated by hyaluronan in the knee joint.
Anatomy & cell biology  •  2010  |  View Paper