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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Carrageenan
drug:
Naproxen
Research Papers that Mention the Interaction
“Single administration of both …–ibuprofen and zinc naproxen (20 mg/kg equivalent to ibuprofen and naproxen, respectively) and their parent drugs and physical mixtures with zinc hydroaspartate (… and 14.37 mg/kg), caused a significant reduction of the edema after the same time from the carrageenan injection in … groups.”
Evaluation of anti-inflammatory and ulcerogenic potential of zinc–ibuprofen and zinc–naproxen complexes in rats“ Naproxen produced a moderate attenuation of carrageenan inflammation and hyperalgesia.”
“ Naproxen at a dose of 15 mg/kg showed anti-inflammatory activity at 1, 2, 3, 4 and 5 hours after administration of carrageenan with suppression of oedema development by 59, 81, 73, 60 and 39% (p = 0.03; 0.001; 0.001; 0.001 and 0.01), respectively.”
Rat paw oedema modeling and NSAIDs: Timing of effects.“Tactile allodynia was similarly inhibited by ~45% 4 h after CGN by both naproxen (at 1, 3 and 10 mg/kg) and ATB-346 (at 1.6 and 4.8 mg/kg; P < 0.001), as well as leukocyte infiltration.”
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