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“ CRGs were able to increase the synthesis of anti-inflammatory interleukin 10 ( IL-10 ) in vitro, and, at low concentrations, their activity in the mixture with LPS was higher.”
“4 Hyperalgesic responses to carrageenin (100 μg) were inhibited by IL‐10 (10 ng) when this cytokine was injected before but not after the carrageenin.”
“5 A monoclonal antibody to mouse IL‐10 potentiated the hyperalgesic responses to carrageenin (10 μg) and TNFα (0.025 pg) but not that to IL‐8 (0.01 ng).”
“7 These data suggest that IL‐10 limits the inflammatory hyperalgesia evoked by carrageenin and bradykinin by two mechanisms: inhibition of cytokine production and inhibition of IL‐1β evoked PGE2 production.”
British journal of pharmacology • 1995 | View Paper
“It was established that κ/β-carrageenan given orally at a dose of 100 mg/kg stimulates the induction of anti-inflammatory cytokines ( IL-10 ) in mouse blood cells by more than 2.5-fold compared with control, with no effect on pro-inflammatory cytokine (TNF-α) production.”
“Pretreating mice with carrageenan once a day before injecting LPS increased the levels of IL-10 by 2.5-fold and reduced TNF-α production by 2-fold compared with control.”
Journal of biomedical materials research. Part A • 2017 | View Paper
“The secretion of interleukin-4 (IL-4), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) also significantly increased after κ-carrageenan administration.”