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Last Updated: a year ago

Possible Interaction: Carrageenan and Interleukin-10

Research Papers that Mention the Interaction

CRGs were able to increase the synthesis of anti-inflammatory interleukin 10 ( IL-10 ) in vitro, and, at low concentrations, their activity in the mixture with LPS was higher.
Marine drugs  •  2020  |  View Paper
4 Hyperalgesic responses to carrageenin (100 μg) were inhibited by IL‐10 (10 ng) when this cytokine was injected before but not after the carrageenin.
5 A monoclonal antibody to mouse IL‐10 potentiated the hyperalgesic responses to carrageenin (10 μg) and TNFα (0.025 pg) but not that to IL‐8 (0.01 ng).
7 These data suggest that IL‐10 limits the inflammatory hyperalgesia evoked by carrageenin and bradykinin by two mechanisms: inhibition of cytokine production and inhibition of IL‐1β evoked PGE2 production.
British journal of pharmacology  •  1995  |  View Paper
It was established that κ/β-carrageenan given orally at a dose of 100 mg/kg stimulates the induction of anti-inflammatory cytokines ( IL-10 ) in mouse blood cells by more than 2.5-fold compared with control, with no effect on pro-inflammatory cytokine (TNF-α) production.
Pretreating mice with carrageenan once a day before injecting LPS increased the levels of IL-10 by 2.5-fold and reduced TNF-α production by 2-fold compared with control.
Journal of biomedical materials research. Part A  •  2017  |  View Paper
The secretion of interleukin-4 (IL-4), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) also significantly increased after κ-carrageenan administration.
BMC Gastroenterology  •  2016  |  View Paper