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Last Updated: a year ago

Possible Interaction: Carrageenan and Indomethacin

supplement:

Carrageenan

Research Papers that Mention the Interaction

In carrageenan induced rat paw edema, ML3000 and indomethacin completely blocked the formation of PGE2 in the inflamed tissue.
Inflammation Research  •  2002  |  View Paper
HT, celecoxib, and indomethacin significantly suppressed swelling in carrageenan-injected rat paws.
Biological & pharmaceutical bulletin  •  2019  |  View Paper
In the carrageenan model of inflammation, pretreatment of rats with indomethacin (10 mg/kg) or CLO (400 mg/kg) induced a significant (p < 0.05) reduction by 31.3 and 27.4%, respectively, in rat paw oedema as compared with the carrageenan-treated group.
Pharmaceutical biology  •  2017  |  View Paper
Histopathological analysis of the CG-injected cheek revealed oedema formation with little leukocyte recruitment at 1–3 h, … 6 h, and a mixed polymorphonuclear and mononuclear cell infiltrate by 24 h. Histamine and serotonin antagonists and indomethacin , but not the NK1 antagonist, decreased … the first 4 h following carrageenan.
Inflammopharmacology  •  2016  |  View Paper
In addition, indomethacin administered into the L5-DRG prevented the increase of PKCε expression in DRG membrane cells induced by carrageenan.
Proceedings of the National Academy of Sciences  •  2013  |  View Paper
Both simvastatin and indomethacin administered orally, 1 hr before carrageenan injection, significantly reduced the extent of footpad oedema.
Basic & clinical pharmacology & toxicology  •  2009  |  View Paper
In the carrageen-induced mouse paw … test, the group treated with indomethacin showed the strongest inhibition of edema formation by 77.8% in the third hour after carrageenan administration, while DMCB (1000mg/kg), CSE (200mg/kg) and CPE (200mg/kg) showed 48.4%, 55.6% and 40.5%, respectively.
Journal of ethnopharmacology  •  2008  |  View Paper
Intraperitoneal pretreatment with indomethacin (20 mg/kg) attenuated carrageenan evoked CT alterations as well as progression of paw swelling and thermal hyperalgesia.
PAIN  •  2008  |  View Paper
At 200 mg/kg the chloroform extract showed maximum inhibition of 48.12% in carrageenan-induced rat paw oedema while the standard indomethacin inhibited it by 54.32% after 3 h of carrageenan injection.
Journal of ethnopharmacology  •  2006  |  View Paper
Blockade of prostaglandin synthesis by indomethacin prior to initiation of inflammation by carrageenan significantly attenuated the TMJ hyperalgesia.
The journal of pain : official journal of the American Pain Society  •  2006  |  View Paper
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