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Last Updated: 2 years ago

Possible Interaction: Carrageenan and Hoe 140




Hoe 140

Research Papers that Mention the Interaction

Intraplantar co-injection of HOE140 (0.1, 1 and 10 micrograms) with carrageenan significantly reduced the carrageenan-evoked paw (25 +/- 7%, 41 +/- 6% and 41 +/- 3% reduction; P < 0.001 for all) and ankle (46 +/- 6%, 61 +/- 5% and 61 +/- 5% reduction; P < 0.001 for all) oedema.
European journal of pharmacology  •  1997  |  View Paper
On its own, HOE140 (3.25 x 10(-7) mol/ paw, intraplantar) had no effect on liver and serum T-kininogen levels but it significantly enhanced liver T-kininogen concentrations in rats pretreated with carrageenan at 8 and 24 h postinjection.
Whereas the B2 antagonist, HOE140 , dose-dependently inhibited the paw edema induced by intraplantar injection of carrageenan , the B1 receptor agonist [Sar(D-Phe8)des-Arg9]BK and antagonist [Lys(Leu8)des-Arg9]BK were ineffective.
Peptides  •  1996  |  View Paper