Possible Interaction: Carrageenan and Histamine

“Decreased reactions to intracutaneously injected histamine and serotonin, inhibited swelling reaction to carrageenin , injected into one of the hind paws, and depressed primary and secondary reactions to adjuvant (heat-killedM. tuberculosis), only occurred in the hyperthyroid group.”

“They have marked suppressive effect on … fresh egg protein, carrageenin, histamine and 5-HT, on the mouse's ear oedema induced by bimethylphenyl, on the exudate and proliferation of granulation … migration and on the contents of PGE in the exudate of the swelling hind paw induced by injecting carrageenin.”

“ Histamine also reduced the cellular influx when administered in combination with an intrapleural injection of carrageenan.”

“It has been known for some time that orally administered degraded carrageenan , apart from possessing antipeptic activity, also causes a temporary reduction of gastric acidity in response to histamine (Anderson, Marcus & Watt, 1962).”

“The results indicate that carrageenin parenterally has a pronounced inhibitory action on the acid secretory response to histamine but, somewhat paradoxically, not on the secretory response to ‘Histalog’ (betazole hydrochloride), a structural isomer of histamine.”

“SrR,-Recently it was found that parenterally administered degraded carrageenan markedly inhibits the gastric secretory response of the guinea-pig to histamine but not to 3-(2-aminoethyl)pyrazole dihydrochloride (ametazole hydrochloride; Histalog) (Watt, Eagleton & Marcus, 1966).”