Possible Interaction: Carrageenan and Dexamethasone

“Oral administration of the EOAS (20 and 200 mg/kg) and subcutaneous injection of dexamethasone (0.5 mg/kg, reference drug) significantly inhibited carrageenan- and complete Freund's adjuvant-induced mouse paw edema.”

“… carrageenin (100 μg), bradykinin (500 ng), TNFα (2.5 pg), IL‐1β (0.5 pg), and IL‐6 (1.0 ng), … not responses to IL‐8 (0.1 ng), PGE2 (100 ng) and dopamine (10 μg), were inhibited by pretreatment with dexamethasone (0.5 mg kg−…, subcutaneously, s.c.,”

“Although dexamethasone significantly suppressed paw edema induced by carrageenan , wogonin had no effect on the anti‐inflammatory action of dexamethasone.”

“The exudate volume was also significantly decreased when indomethacin, a cyclooxygenase inhibitor, or dexamethasone , a steroidal antiinflammatory drug, was coinjected with carrageenan.”

“When administered at 2 h postcarrageenin , there was no effect at 3 h; but at 6 h, dexamethasone significantly reduced the swelling.”

“ Dexamethasone dramatically attenuated both carrageenan hyperalgesia and inflammation.”

“Finally, carrageenan administration produced a time-dependent increase in cellular infiltration into the pouch exudate that was inhibited by dexamethasone and NOS inhibitors.”

“Exudate volume and leukocyte number in the pleural cavity at 3 h after the carrageenin injection were significantly reduced by the pretreatment with indomethacin or dexamethasone.”

“The anti-inflammatory effect of dexamethasone in carrageenin rat paw oedema was significantly reduced or abolished by local injection of 0.5-2.5 mg of the antiglucocorticoid progesterone, or of 5 micrograms cycloheximide, or of 2.5 micrograms actinomycin D, into the oedematous area.”

“These proteins, as well as dexamethasone itself, inhibited the hind-paw rat oedema induced by carrageenin.”