Possible Interaction: Carotenoids and Vitamin C

“These carotenoids were at least 5 times more effective than quercetin, trolox, and ascorbic acid (positive controls).”

“Studies of fat- and water-soluble antioxidants sufficiency (retinol, alfa- and gamma-tocopherols, alfa- and beta-carotene, lycopene, …, ascorbic and uric acids) and lipid spectrum in patients with cardiovascular disease revealed that blood levels of some carotenoids are directly … levels of vitamin C and to levels … high-density lipoproteins.”

“… carotenoids … vitamin C were significant predictors of their respective plasma concentration (P<0.01), and that BMI was inversely associated with plasma concentration of carotenoids (P< … to a lower extent beta-carotene, suggesting that these intakes in subjects with high BMI were not good predictors of their plasma concentration.”

“In terms of nutrients, bladder cancer risk was inversely associated with intake of both total carotenoids (p = 0.004) and vitamin C (p = 0.02).”

“There was a close correlation (r = 0.58, p = 0.0001) between intakes of total carotenoids and vitamin C in study subjects.”

“Recently it has been demonstrated that carotenoids react cooperatively and synergistically with vitamin C and E, serving to regenerate a pro-oxidant radical carotenoid after the antioxidant reduction of a radical species.”

“ Ascorbic acid pretreatment increased the retention of total carotenoids , ß‐carotene, TPC, and TFC (p < .05) by (6–11)%, (8–34)%, (7–58)%, and (6–30)%, respectively, for all the drying methods.”

“Application of AsA contributes to an increase in antioxidant enzymes activity such as SOD, CAT, POD and proline contents, chlorophyll a and b, total chlorophyll, carotenoids , soluble carbohydrates.”

“The radical cations of the carotenoids all react with vitamin C so as to "repair" the carotenoid.”

“ Ascorbic acid when added in the range of 0-1.8 mM interacted with the different carotenoids by different modes.”