Possible Interaction: Carotenoids and Tretinoin

“Similarly, laboratory evidence points to a carcinogenesis inhibitory role for both retinoids and carotenoids.”

“Several studies have evaluated the possible association between intakes of retinoids and carotenoids and the risk of prostate cancer, but the evidence is still inconsistent.”

“We observed inverse associations between breast adipose concentrations of retinoids and carotenoids and risk of breast cancer, although not all were statistically significant.”

“In general, the retinoids inhibited proliferation; the action was cytostatic, in rank order tretinoin > isotretinoin > etretin > arotinoid.”

“In conclusion, carotenoids and retinoids may have direct effects on the inter-species differences in CYP1A-dependent activity and protein expression.”

“Certain carotenoids that are precursors of these retinoids also displayed considerable inhibitory capacity.”

“These differentiation processes were inhibited by retinoic acid at 10(-6) M and by the arotinoid containing tetramethylated tetraline (Ro 13-7410) at 10(-10) M. The presence of this arotinoid for as little as 5 min, followed by incubation in control medium, irreversibly suppressed lobuloalveolar differentiation.”

“Competition by the arotinoids with all-trans-retinoic acid for sites on the cellular retinoic acid-binding protein is qualitatively consistent with their capacity for promoting differentiation.”

“… retinoic acid … carotenoid content of serum, liver, and skin to a greater extent than other forms of vitamin A. In an experiment designed to study the … combination with thyroxine or thiouracil on the utilization of carotenoids, a similarity of their effects between high vitamin A and thiouracil was evident.”

“ Carotenoid exposure in early placental development, significantly modify the placenta gene expression related to retinoid pathways and maternal to fetal transfer.”