Possible Interaction: Carotenoids and Tocopherols

“Previous studies suggest that carotenoids and tocopherols (vitamin E compounds) may be inversely associated with prostate cancer risk, yet little is known about how they affect prostate cancer progression and survival.”

“In vitro studies investigating the synergistic effects of mixtures of carotenoids and tocopherols have been hindered due to the difficulty of solubilising these lipophilic compounds.”

“ Tocopherols and carotenoids were significantly correlated with each other (P<0.05) in maternal and cord plasma.”

“ Carotenoids were positively correlated with plant height as well as foliar and floral traits but negatively correlated with tocopherols.”

“ Carotenoids and tocopherols showed weak correlation with 2,2-diphenyl-1-picrylhydrazyl (DPPH) activity (r=0.4893 and 0.3259, respectively), but good correlation when combined (r=0.6688), suggesting they may act synergistically.”

“There is a body of evidences demonstrating, in biological systems, a cooperative interaction between tocopherols and carotenoids.”

“The tocopherol-deficient mutants were also more susceptible to HL treatment in the presence of sublethal levels of norflurazon, an inhibitor of carotenoid synthesis, suggesting carotenoids and tocopherols functionally interact or have complementary or overlapping roles in protecting Synechocystis sp. strain PCC 6803 from lipid peroxidation and HL stress.”