Possible Interaction: Carotenoids and Lutein

“β-Carotene, α-carotene, lycopene and lutein were increased in the plasma of subjects consuming the carotenoid mixture.”

“With the association between increased carotenoid intake and lower risk of chronic diseases, the absorption of lutein from the diet becomes an important factor in its delivery and physiological action.”

“We hypothesized that increased consumption of eggs, lutein , and zeaxanthin may correlate with decreased absorption of other carotenoids and increased absorption of vitamins A and E, thus affecting their serum concentrations and lipoprotein distribution.”

“Here, we examined if LUT and ZEA attenuate the bioaccessibility of pro-VA carotenoids at amounts and ratios present in maize.”

“However, available food sources of lutein contain only modest amounts of the carotenoid.”

“In terms of nutrients, there were significant inverse associations of RCC risk with consumption of a variety of carotenoids including alpha‐carotene (p < 0.001), beta‐carotene (p = 0.004), beta‐cryptoxanthin (p = 0.01) and lutein (p = 0.005).”

“ Lower lutein concentrations in recipients of beta-carotene capsules suggested an interaction between these two carotenoids.”

“In rhesus infants, increased intake of carotenoids from formula enhanced their deposition in serum and numerous tissues and selectively increased lutein in multiple brain regions.”

“Meanwhile, all MIC-LR concentrations caused an increase in the superoxide dismutase (SOD) expression, while catalase (CAT) expression was only affected at 500 μg/L. The carotenoid LUT prevented the ROS generation, impairment in the CAT expression, and the survival loss induced by MIC-LR in C. elegans.”

“Results showed that in ovo xanthophyll modulated carotenoid and retinoid metabolism mainly within one wk after hatching.”