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Last Updated: 4 months ago

Possible Interaction: Carnosine and Vigabatrin



Research Papers that Mention the Interaction

Larger doses of vigabatrin (4 g) further increased homocarnosine but changed GABA levels minimally.
Annals of neurology  •  1998  |  View Paper
VGB increases human brain gamma-aminobutyric acid (GABA) and the related metabolites, homocarnosine and 2-pyrrolidinone.
Epilepsia  •  1999  |  View Paper
The GVG dose reduction resulted in a concomitant decrease in TGABA, FGABA, HC and GVG (P less than 0.001).
British journal of clinical pharmacology  •  1989  |  View Paper
At therapeutic doses in man vigabatrin produces dose-related increases in CSF concentrations of free and total GABA, homocarnosine (the GABA-histidine dipeptide) and beta-alanine.
British journal of clinical pharmacology  •  1989  |  View Paper
CSF free and total Gaba and homocarnosine concentrations increased from three to five fold with GVG treatment.
Journal of neurology, neurosurgery, and psychiatry  •  1987  |  View Paper
Treatment of rats with gamma-vinyl-GABA , an inhibitor of GABA-transaminase, caused a dose- and time-related increase in brain GABA concentrations concomitant with increases in the concentrations of total GABA and homocarnosine in the CSF.
Neuroscience Letters  •  1983  |  View Paper