Possible Interaction: Carnosine and Pyrilamine

“Carnosine prevented the cell damage, rescued the expression of GS and reversed the glutamate uptake activity and glutamine production in the senescent astrocytes exposed to OGD/R. The modulatory effect of carnosine on GS expression was partly antagonized by pyrilamine , a selective histamine H1 receptors antagonist, but not bestatin.”

“ Pyrilamine and thioperamide, selective central histamine H(1) and H(3) antagonists also significantly reversed the protection of carnosine.”

“The protective effect of carnosine was antagonized by the H1 receptor antagonist pyrilamine , but not by the H2 receptor antagonist cimetidine.”

“Carn with an apparent IC(50) ….45 microM. Like histamine, carnosine evoked an H2-mediated (cimetidine-…) relaxation in the presence of mepyramine , but was less potent (10.8 +/- 3.1% of initial tension remaining at 10 … carnosine compared with 13.4 +/- 7.5% remaining at 0.1 mM histamine).”

“8 Like histamine, carnosine evoked an H2‐mediated (cimetidine‐sensitive) relaxation in the presence of mepyramine , but was less potent (10.8±3.1% residual tension at 10 mm carnosine compared with 13.4±7.5% at 0.1 mm histamine).”

“… Carnosine , with Zn present, …‐specific binding of [3H]‐mepyramine to isolated guinea‐pig cerebellar membranes (log IC50s−2.78±0.02, −3.93±0.03 and −4.64±0.…, 30 and 80 μm Zn respectively; values corrected for the Zn‐specific inhibition which has a logIC50 of −4.20).”