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Last Updated: a year ago

Possible Interaction: Carnosine and Pyrilamine

supplement:

Carnosine

Research Papers that Mention the Interaction

Carnosine prevented the cell damage, rescued the expression of GS and reversed the glutamate uptake activity and glutamine production in the senescent astrocytes exposed to OGD/R. The modulatory effect of carnosine on GS expression was partly antagonized by pyrilamine , a selective histamine H1 receptors antagonist, but not bestatin.
Brain Research Bulletin  •  2017  |  View Paper
Pyrilamine and thioperamide, selective central histamine H(1) and H(3) antagonists also significantly reversed the protection of carnosine.
Biochemical pharmacology  •  2007  |  View Paper
The protective effect of carnosine was antagonized by the H1 receptor antagonist pyrilamine , but not by the H2 receptor antagonist cimetidine.
Neuroscience Letters  •  2007  |  View Paper
Carn with an apparent IC(50) ….45 microM. Like histamine, carnosine evoked an H2-mediated (cimetidine-…) relaxation in the presence of mepyramine , but was less potent (10.8 +/- 3.1% of initial tension remaining at 10 … carnosine compared with 13.4 +/- 7.5% remaining at 0.1 mM histamine).
Biochemistry. Biokhimiia  •  2000  |  View Paper
8 Like histamine, carnosine evoked an H2‐mediated (cimetidine‐sensitive) relaxation in the presence of mepyramine , but was less potent (10.8±3.1% residual tension at 10 mm carnosine compared with 13.4±7.5% at 0.1 mm histamine).
Carnosine , with Zn present, …‐specific binding of [3H]‐mepyramine to isolated guinea‐pig cerebellar membranes (log IC50s−2.78±0.02, −3.93±0.03 and −4.64±0.…, 30 and 80 μm Zn respectively; values corrected for the Zn‐specific inhibition which has a logIC50 of −4.20).
British journal of pharmacology  •  1998  |  View Paper