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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Carnosine
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“ NO S-nitrosylated CN1 and decreased CN1 efficiency for carnosine by 70 % (p < 0.01), but not for anserine.”
Carnosine metabolism in diabetes is altered by reactive metabolites“The protective effects of orally applied non-hydrolyzed formulated species of carnosine include at least the direct interaction with NO , inhibition of cytotoxic NO-induced proinflammatory condition, and attenuation of the effects of cytokines and chemokines that can exert profound effects on inflammatory cells.”
“The protective effects of orally applied nonhydrolized formulated species of carnosine include at least direct interaction with nitric oxide , inhibition of cytotoxic NO-induced proinflammatory condition, and attenuation of the effects of cytokines and chemokines that can exert profound effects on inflammatory cells.”
“The inhibition by carnosine of guanylate cyclase activation by an NO donor is due to the interaction of carnosine with heme iron with subsequent formation of a chelate complex.”
“Specifically, carnosine lowered the oxidative stress by decreasing NO and O2−• intracellular levels as well as the expression of iNOS and Nox enzymes.”
Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1“Results showed that carnosine causes an apparent suppression of total NO production by stimulated macrophages accompanied by an unexpected simultaneous drastic increase in its intracellular low toxicity endproduct, nitrite, with no inhibition of inducible nitric oxide synthase (iNOS).”
“ Carnosine treatment decreased MDA levels, improved RBC (red blood cell) ability to deform, and increased NO levels.”
“It was also found that carnosine can significantly reverse erythrocyte deformability, reduce lipid peroxidation and increase NO levels in diabetes.”
“ Carnosine enhanced NO production in a dose-dependent manner, and the stimulatory effect of carnosine was observed at concentrations exceeding 5 mM. The carnosine-stimulated NO production was inhibited by N(G)-nitro-L-arginine methyl ester, but not by N(G)-nitro-D-arginine methyl ester.”
“ Carnosine had no effect on NO production for the initial 5 min, but thereafter resulted in a gradual increase in NO production up to 15 min.”
“These results indicate that carnosine facilitates NO production in endothelial F-2 cells.”
“A correlation was found between cell protection and NO free‐radical scavenging activity of carnosine.”
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