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Last Updated: a year ago

Possible Interaction: Carnosine and Nitric Oxide

supplement:

Carnosine

Research Papers that Mention the Interaction

NO S-nitrosylated CN1 and decreased CN1 efficiency for carnosine by 70 % (p < 0.01), but not for anserine.
Amino Acids  •  2015  |  View Paper
The protective effects of orally applied non-hydrolyzed formulated species of carnosine include at least the direct interaction with NO , inhibition of cytotoxic NO-induced proinflammatory condition, and attenuation of the effects of cytokines and chemokines that can exert profound effects on inflammatory cells.
Journal of basic and clinical physiology and pharmacology  •  2013  |  View Paper
The protective effects of orally applied nonhydrolized formulated species of carnosine include at least direct interaction with nitric oxide , inhibition of cytotoxic NO-induced proinflammatory condition, and attenuation of the effects of cytokines and chemokines that can exert profound effects on inflammatory cells.
American journal of therapeutics  •  2012  |  View Paper
The inhibition by carnosine of guanylate cyclase activation by an NO donor is due to the interaction of carnosine with heme iron with subsequent formation of a chelate complex.
Biochemistry. Biokhimiia  •  2000  |  View Paper
Specifically, carnosine lowered the oxidative stress by decreasing NO and O2−• intracellular levels as well as the expression of iNOS and Nox enzymes.
Cells  •  2019  |  View Paper
Results showed that carnosine causes an apparent suppression of total NO production by stimulated macrophages accompanied by an unexpected simultaneous drastic increase in its intracellular low toxicity endproduct, nitrite, with no inhibition of inducible nitric oxide synthase (iNOS).
Molecular and Cellular Biochemistry  •  2017  |  View Paper
Carnosine treatment decreased MDA levels, improved RBC (red blood cell) ability to deform, and increased NO levels.
Medical science monitor : international medical journal of experimental and clinical research  •  2014  |  View Paper
It was also found that carnosine can significantly reverse erythrocyte deformability, reduce lipid peroxidation and increase NO levels in diabetes.
Archives of physiology and biochemistry  •  2012  |  View Paper
Carnosine enhanced NO production in a dose-dependent manner, and the stimulatory effect of carnosine was observed at concentrations exceeding 5 mM. The carnosine-stimulated NO production was inhibited by N(G)-nitro-L-arginine methyl ester, but not by N(G)-nitro-D-arginine methyl ester.
Carnosine had no effect on NO production for the initial 5 min, but thereafter resulted in a gradual increase in NO production up to 15 min.
These results indicate that carnosine facilitates NO production in endothelial F-2 cells.
Biological & pharmaceutical bulletin  •  2009  |  View Paper
A correlation was found between cell protection and NO free‐radical scavenging activity of carnosine.
Journal of neuroscience research  •  2007  |  View Paper
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