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Last Updated: a year ago

Possible Interaction: Carnosine and Histidine

supplement:

Carnosine

supplement:

Histidine

Research Papers that Mention the Interaction

After 8 wk, 1.8% carnosine resulted in significant fivefold increases in carnosine and twofold increases in histidine in the soleus muscle (P < or = 0.05).
The Journal of nutrition  •  2001  |  View Paper
In chickens, histidine is particularly important as a limiting factor for carnosine synthesis, which has strong anti-oxidant effects.
Nutrients  •  2020  |  View Paper
These data suggest that histidine and carnosine are potential multiple-protective agents for diabetic complications prevention or therapy.
European journal of pharmacology  •  2005  |  View Paper
In addition, some effects of carnosine are ascribed to the effects of histidine.
Obesity reviews : an official journal of the International Association for the Study of Obesity  •  2020  |  View Paper
In addition, we detected protein and mRNA expression of carnosinases and a low but significant release of l-histidine in cells incubated in the presence of 50 mM carnosine (p < 0.05), which did not correlate with carnosine’s effect on viability.
Amino Acids  •  2019  |  View Paper
In the cell line LN405, the competitive inhibitors β-alanyl-l-alanine (inhibits all transporters) and l-histidine (inhibitor of PHT1/2) both inhibited the uptake of carnosine.
Amino Acids  •  2019  |  View Paper
The post-intake of histidine and carnosine significantly decreased MDA formations, increased GSH content, enhanced catalase and GPX activities, and suppressed CYP2E1 activity (P<0.05), in which the effects on catalase and CYP2E1 activities were dose-dependent (P<0.05).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2008  |  View Paper
Carnosine also can inhibit the glutamate release and increase HDC activity and the intracellular and extracellular contents of carnosine, histidine and histamine detected by high-performance liquid chromatography (HPLC).
Biochemical pharmacology  •  2007  |  View Paper
Histidine , a decomposed product of carnosine, increased in muscles after carnosine administration prior to the increase in kidney and liver.
Comparative biochemistry and physiology. B, Comparative biochemistry  •  1991  |  View Paper
CAR was found to have a membrane-stabilizing effect, which reached a plateau at a final … mM. This membrane stabilizing effect was not observed with beta-ALA or L-histidine ( HIS ) alone at a final concentration of 5 mM, and … enzyme was only slightly inhibited by HIS + beta-ALA.
Nihon seirigaku zasshi. Journal of the Physiological Society of Japan  •  1990  |  View Paper
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