Possible Interaction: Carnosine and Histamine

“To validate this hypothesis, we demonstrated the existence of carnosine in multiple histamine-rich tissues in several mammalian species; documented … link between carnosine and histidine, histamine and 3-methylhistamine (a degradation product of histamine) in unstressed animals, and showed that tissue carnosine is decreased simultaneously … increase in tissue histamine ….”

“ Carnosine also can inhibit the glutamate release and increase HDC activity and the intracellular and extracellular contents of carnosine, histidine and histamine detected by high-performance liquid chromatography (HPLC).”

“9 Carnosine , like mepyramine, can ‘reveal’ the H2‐mediated relaxation of histamine providing further evidence that carnosine binds at the H1 receptor.”

“Thus, the enhancement by carnosine of wound healing may be ascribed to stimulation of early effusion by histamine and of collagen biosynthesis by beta-alanine.”

“It was found that carnosine , like metiamide, an H-2 antagonist of histamine, is capable of inhibiting the histamine caused suppression of T rosette-formation by guinea-pig blood and spleen lymphocytes.”

“In the second experiment of this study, histamine or histidine treatment was shown to prevent trauma-induced reductions of tissue carnosine but was less effective in ameliorating tissue anserine loss.”