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“ATP in cell lysates and dehydrogenase activity in living cells revealed a strong reduction of viability under the influence of carnosine when cells received glucose or galactose but not in the presence of pyruvate.”
“ l-Carnosine supplementation to MetS rats significantly reduced abdominal obesity, blood pressure and glucose , and normalized total cholesterol and low density lipoprotein cholesterol levels (P < 0.05).”
“Supplementation with carnosine or β-alanine may reduce fasting glucose , HbA1c, and HOMA-IR in humans and rodents, and fasting insulin in humans; both compounds show potential as therapeutics to improve glycemic control and insulin resistance.”
“Co-incubation of carnosine (1 mM) and glucose (25 mM) induced further upregulation of Hsp70 (84%), Sirt-1 (52%), Trx (35%), γ-GCS (90%) and HO-1 (73%) concentrations compared to untreated cells (all p < 0.001).”