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Last Updated: a year ago

Possible Interaction: Carnosine and Copper





Research Papers that Mention the Interaction

Studies have shown that (i) the olfactory lobe is normally enriched in carnosine and zinc, (ii) carnosine can suppress copper and zinc toxicity in olfactory neurones, (iii) olfactory dysfunction is often associated with neurodegenerative conditions and (iv) elevated levels of zinc are found in brains of Alzheimer’s patients.
Biogerontology  •  2005  |  View Paper
Also, CAR exposure upregulated CAR biosynthesis ( Carns1), extracellular degradation ( Cndp1), and transport ( Slc15a4, alias Pht1) genes and elicited CAR intracellular accumulation, contributing to the outline of functional association between CAR and Cu within the cell.
Here, we report that CAR intercepts the regulatory routes of Cu homeostasis in nervous cells and tissues.
American journal of physiology. Cell physiology  •  2019  |  View Paper
Ten micromolar copper halved the currents evoked by ATP in both receptors; co‐application of carnosine plus copper prevented the metal induced‐inhibition with a median effective concentration of 12.1 ± 3.9 and 12.0 ± 5.5 µm for P2X4 and P2X7, respectively.
Journal of neurochemistry  •  2002  |  View Paper
Inhibition of the oxidation of phosphatidylcholine liposomes by purified carnosine is greater in the presence of copper than iron, a phenomenon likely to be due to the copper chelating properties of carnosine.
Biochemistry. Biokhimiia  •  2000  |  View Paper
Recently, we demonstrated that carnosine , a dipeptide expressed in glial cells throughout the brain as well as in neuronal pathways of the visual and olfactory systems, can modulate the effects of zinc and copper on neuronal excitability.
This result led us to hypothesize that carnosine may modulate the neurotoxic effects of zinc and copper as well.
Brain Research  •  2000  |  View Paper
Carnosine prevented the actions of copper and reduced the effects of zinc.
These results suggest that carnosine may indirectly influence neuronal excitability by modulating the effects of zinc and copper.
Neuroreport  •  1998  |  View Paper
Carnosine , homocarnosine and anserine significantly inhibited the fragmentation and inactivation of Cu ,Zn-SOD by AAPH.
Oxidation of amino acid residues in Cu ,Zn-SOD induced by AAPH were significantly inhibited by carnosine and related compounds.
Biochimica et biophysica acta  •  2002  |  View Paper
Carnosine , homocarnosine and anserine effectively inhibited the formation of *OH by the Cu ,Zn-SOD/H(2)O(2) system.
The results showed that carnosine , homocarnosine and anserine significantly protected the fragmentation of Cu ,Zn-SOD.
Biochimica et biophysica acta  •  1999  |  View Paper
Furthermore, carnosine inhibited the oxidative hydroxylation of deoxyguanosine induced by ascorbic acid and copper ions.
Proceedings of the National Academy of Sciences of the United States of America  •  1988  |  View Paper