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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Studies have shown that (i) the olfactory lobe is normally enriched in carnosine and zinc, (ii) carnosine can suppress copper and zinc toxicity in olfactory neurones, (iii) olfactory dysfunction is often associated with neurodegenerative conditions and (iv) elevated levels of zinc are found in brains of Alzheimer’s patients.”
Could carnosine suppress zinc-mediated proteasome inhibition and neurodegeneration? Therapeutic potential of a non-toxic but non-patentable dipeptide“Also, CAR exposure upregulated CAR biosynthesis ( Carns1), extracellular degradation ( Cndp1), and transport ( Slc15a4, alias Pht1) genes and elicited CAR intracellular accumulation, contributing to the outline of functional association between CAR and Cu within the cell.”
“Here, we report that CAR intercepts the regulatory routes of Cu homeostasis in nervous cells and tissues.”
Carnosine modulates the Sp1-Slc31a1/Ctr1 copper-sensing system and influences copper homeostasis in murine CNS-derived cells.“Ten micromolar copper halved the currents evoked by ATP in both receptors; co‐application of carnosine plus copper prevented the metal induced‐inhibition with a median effective concentration of 12.1 ± 3.9 and 12.0 ± 5.5 µm for P2X4 and P2X7, respectively.”
“Inhibition of the oxidation of phosphatidylcholine liposomes by purified carnosine is greater in the presence of copper than iron, a phenomenon likely to be due to the copper chelating properties of carnosine.”
“Recently, we demonstrated that carnosine , a dipeptide expressed in glial cells throughout the brain as well as in neuronal pathways of the visual and olfactory systems, can modulate the effects of zinc and copper on neuronal excitability.”
“This result led us to hypothesize that carnosine may modulate the neurotoxic effects of zinc and copper as well.”
“ Carnosine prevented the actions of copper and reduced the effects of zinc.”
“These results suggest that carnosine may indirectly influence neuronal excitability by modulating the effects of zinc and copper.”
“ Carnosine , homocarnosine and anserine significantly inhibited the fragmentation and inactivation of Cu ,Zn-SOD by AAPH.”
“Oxidation of amino acid residues in Cu ,Zn-SOD induced by AAPH were significantly inhibited by carnosine and related compounds.”
Protective effects of carnosine, homocarnosine and anserine against peroxyl radical-mediated Cu,Zn-superoxide dismutase modification.“ Carnosine , homocarnosine and anserine effectively inhibited the formation of *OH by the Cu ,Zn-SOD/H(2)O(2) system.”
“The results showed that carnosine , homocarnosine and anserine significantly protected the fragmentation of Cu ,Zn-SOD.”
“Furthermore, carnosine inhibited the oxidative hydroxylation of deoxyguanosine induced by ascorbic acid and copper ions.”
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