Possible Interaction: Carnitine and Simvastatin

“Indeed, our study shows that, at the highest dose of simvastatin , creatine kinase (CK) plasma levels were significantly elevated in treated animals compared with controls and that carnitine coadministration efficiently counteracted plasma CK levels in the former group (Table 1).”

“We observed that patients treated with carnitine and simvastatin showed a reduction in small-sized LDL proportion and an increase in LDL particle size.”

“Conclusions: The coadministration of carnitine and simvastatin resulted in a significant reduction in Lp(a) and apo(a) and may represent a new therapeutic option in reducing plasma Lp(a) levels, LDL cholesterol and Apo B100.”

“Results: At the … in the carnitine … simvastatin combined group compared with the simvastatin alone group, we observed a significant decrease in glycemia (p < 0.001), tryglicerides (p < 0.… B (p < 0.05), Lp(a) (p < 0.05), apo(a) (p < 0.05), while HDL significantly increased (p < 0.05).”