Possible Interaction: Carnitine and Palmitic Acid

“Administration of L-lutein, carnitine , combined to normal rats significantly decreased the levels of myristic, palmitice , palmitoleic, stearic, linoleic, α-linolenic, arachidic and eicosadienoic when compared with control normal rats (p<0.001).”

“The absorption of palmitic acid was decreased in the presence of D-carnitine (10 mg/ml) as evidenced by significantly lower levels of radioactivity in the gut wall and the plasma and by significantly greater residual radioactivity in the lumenal contents.”

“ Carnitine partially reverses the inhibition of pyruvate and palmitic acid oxidation by propionic acid, and this reversal is associated with increased propionylcarnitine formation.”

“Both palmityl carnitine and palmitic acid inhibited, whereas oleic acid stimulated initial calcium uptake.”

“In the culture medium of primary human skeletal muscle cells, NAT and ACT concentrations significantly increased when they were cultured with taurine and acetate or with carnitine and palmitic acid , respectively.”

“The increase in the mitochondrial acetyl-CoA/free CoA ratio induced by acetate and palmitic acid was suppressed by taurine and carnitine , respectively.”