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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Addition of carnitine partially reversed the inhibitory effects of octanoate on acetyl-CoA carboxylase expression, suggesting that a metabolite of octanoate is involved in mediating this response.”
Arachidonate and medium-chain fatty acids inhibit transcription of the acetyl-CoA carboxylase gene in hepatocytes in culture.“These data confirm the hypothesis that carnitine effects the in vivo oxidation of octanoate in colostrum-deprived piglets and suggest that the effects may be mediated by aiding the export of excess acetyl groups from muscle or by enhancing uptake of octanoate into liver mitochondria.”
“ Carnitine addition prevented the inhibition of octanoate oxidation but not that of butyrate.”
“This inhibition of octanoate oxidation was also prevented by carnitine addition.”
“Although the addition of carnitine enhanced the oxidation of palmitate and octanoate by homogenates from both healthy and cardiomyopathic hamsters, the magnitude of the depression of oxidation (60–80%) in the myopathic homogenates was not influenced by carnitine.”
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