Possible Interaction: Carnitine and Long Chain Fatty Acid

“ Carnitine reinforces the utilization of long chain fatty acids and thus improves the energy conversion.”

“ Carnitine stimulates the catabolism of long-chain fatty acids (FAs), by transporting them to mitochondria for oxidation, and the intracellular decomposition of branched-chain ketoacids.”

“Lower free carnitine levels in soybean oil-based group is the result of carnitine need during the mitochondrial transport of long chain fatty acids.”

“ Carnitine has an essential role in the mitochondrial oxidation of long-chain fatty acids.”

“Since the carnitine plays a regulatory role in the mitochondrial oxidation of the long chain fatty acids , loss of OCTN2 function lead to severe impairment of the intracellular metabolism at biochemical level, which can explain the development of a severe, even life threatening condition.”

“In contrast, it is suggested that the availability of free carnitine may play a major regulatory role in oxidation of LCFA during exercise.”

“BACKGROUND Carnitine , a quaternary amino acid, plays an important role in the oxidation of long chain fatty acids.”

“Raising carnitine levels could improve substrate delivery for mitochondrial β-oxidation of long-chain fatty acids , thus reducing the use of VLCFA as substrates for β-oxidation.”

“Whenever long-chain fatty acids are to be used for energy generation, their binding to carnitine is mandatory for their translocation into the mitochondria (Fig. 2).”

“Soon after the role of carnitine in facilitating /3-oxidation of long-chain fatty acids was identified, altered carnitine status of patients treated with hemodialysis compared with that of healthy individuals was interpreted by several investigators as a state of carnitine deficiency (2).”

“The hypothesis seems plausible if the major function of carnitine is to facilitate a-oxidation of long-chain fatty acids.”