Possible Interaction: Carnitine and Levocarnitine

“ L-carnitine supplementation resulted in significant carnitine plasma level increase by week 4.”

“ L-Carnitine treatment prevented this fall in plasma carnitine and resulted in greater increases in excretion of acylcarnitines.”

“Intravenous L-carnitine treatment increased plasma carnitine concentrations, improved patient-assessed fatigue, and may prevent the decline in peak exercise capacity in hemodialysis patients.”

“ L-Carnitine supplementation increased plasma carnitine concentrations, but did not affect VO(2max) in either study.”

“After L-carnitine supplementation in eleven patients with hypocarnitinemia, the concentrations of carnitine were significantly increased.”

“By contrast, total and free carnitine levels were markedly increased (p < 0.01) after supplementation with L-carnitine.”

“Furthermore, in a randomly-selected hemodialysis population, L-carnitine injection at the dose of 20 mg/kg results in significant increases in blood (and perhaps tissue) carnitine levels, but this is not associated with any major effects on lipid profiles.”

“When L-carnitine was added to the dialysate, total carnitine was observed to significantly increase in the group receiving 4 g.(ABSTRACT TRUNCATED AT 250 WORDS)”

“This work suggest that the daily administration during a long period, of 2 g of L-carnitine guarantee in a healthy subject blood carnitine concentrations superior to the normal levels.”

“In contrast, treatment with L-carnitine increased plasma carnitine levels by 80% and the skeletal muscle carnitine content by 50%.”

“After intestinal absorption, L- and D-carnitine is transferred to organs whose metabolism is dependent on fatty acid oxidation, such as heart and skeletal muscle, and D-carnitine competitively depletes muscle level of L-carnitine.”

“There is some evidence that L-carnitine and D-carnitine compete for uptake in small intestine and tubular re-absorption in kidneys.”

“Whereas L-carnitine is found to be essential for the oxidation of fatty acids, D-carnitine causes a depletion of L-carnitine , and hindered fatty acid oxidation and energy formation.”