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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Carnitine and Ifosfamide



Research Papers that Mention the Interaction

Therefore, this study has been initiated to investigate, on gene expression level, the mechanism of IFO-induce nephrotoxicity and those whereby carnitine supplementation attenuates this serious side effect of IFO.
Oxidative medicine and cellular longevity  •  2012  |  View Paper
RESULTS Administration of IF fo r 5 consecutive days significantly increased serum creatinine, blood urea nitrogen (BUN), uri nary carnitine ex cretion, intramitochondrial acetyl-CoA and thiobarbituric acid reactive substances (TBARS), and significantly decreased total carnitine, intramitochondrial CoA-SH, ATP and ATP/ADP ratio, and reduced glutathione (GSH) in kidney tissues.
Journal of nephrology  •  2011  |  View Paper
IFO significantly increased serum creatinine, blood urea nitrogen (BUN), urinary carnitine excretion and clearance, creatine phosphokinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), …-CoA/CoA-SH and thiobarbituric acid reactive substances (TBARS) in cardiac tissues and significantly decreased adenosine triphosphate (ATP) and total carnitine and reduced glutathione (… in cardiac tissues.
In carnitine-depleted rats, IFO induced dramatic increase in serum creatinine, BUN, CK-MB, LDH, carnitine clearance and intramitochondrial acetyl-CoA/CoA-SH, as well as progressive reduction in total carnitine and ATP in cardiac tissues.
Oxidative medicine and cellular longevity  •  2010  |  View Paper
Prototypes of anticancer drugs that alter carnitine system are doxorubicin, cisplatin, carboplatin, oxaliplatin, cyclophosphamide and ifosfamide.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society  •  2010  |  View Paper