Possible Interaction: Carnitine and Ifosfamide

“Therefore, this study has been initiated to investigate, on gene expression level, the mechanism of IFO-induce nephrotoxicity and those whereby carnitine supplementation attenuates this serious side effect of IFO.”

“RESULTS Administration of IF fo r 5 consecutive days significantly increased serum creatinine, blood urea nitrogen (BUN), uri nary carnitine ex cretion, intramitochondrial acetyl-CoA and thiobarbituric acid reactive substances (TBARS), and significantly decreased total carnitine, intramitochondrial CoA-SH, ATP and ATP/ADP ratio, and reduced glutathione (GSH) in kidney tissues.”

“ IFO significantly increased serum creatinine, blood urea nitrogen (BUN), urinary carnitine excretion and clearance, creatine phosphokinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), …-CoA/CoA-SH and thiobarbituric acid reactive substances (TBARS) in cardiac tissues and significantly decreased adenosine triphosphate (ATP) and total carnitine and reduced glutathione (… in cardiac tissues.”

“In carnitine-depleted rats, IFO induced dramatic increase in serum creatinine, BUN, CK-MB, LDH, carnitine clearance and intramitochondrial acetyl-CoA/CoA-SH, as well as progressive reduction in total carnitine and ATP in cardiac tissues.”

“Prototypes of anticancer drugs that alter carnitine system are doxorubicin, cisplatin, carboplatin, oxaliplatin, cyclophosphamide and ifosfamide.”