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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Carnitine
Research Papers that Mention the Interaction
“There was a significant increase in free and total carnitine levels after treatment for patients receiving doxorubicin than patients receiving cisplatin or ifosfamide.”
Carnitine Plasma Levels and Fatigue in Children/Adolescents Receiving Cisplatin, Ifosfamide, or Doxorubicin“In conclusion, l‐carnitine attenuated the long‐term alterations caused by doxorubicin in the germ cells and improved male reproductive capacity in adulthood.”
Carnitine partially improves oxidative stress, acrosome integrity, and reproductive competence in doxorubicin‐treated rats“For heart, DOX exposure caused decline of lipid, lactate, leucine, alanine, glutamate, choline, xanthine, glycerin, carnitine , and fumarate, together with elevation of glutamine, creatine, inosine, taurine and malate.”
“ Carnitine reduced the late testicular and spermatic damages caused by doxorubicin , probably providing a partial cytoprotection against the deleterious action of doxorubicin administration to pre‐pubertal rats.”
“Taken together, these findings show that by inhibiting …‐activated acid sphingomyelinase and ceramide generation, L‐carnitine … doxorubicin‐induced apoptosis of cardiac myocytes.—Andrieu‐Abadie, N., Jaffrézou, J.‐P., Hatem, S., Laurent, G., Levade, T., …. L‐carnitine prevents doxorubicin‐induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation.”
“It has been found that adriamycin almost abolishes the activating effect of carnitine on state 2 respiration.”
“It was concluded from this study that 1) a relationship exists … the number of IML in normal murine cardiac muscle; 2) carnitine produces an inverse … normal relationship; 3) adriamycin disturbs the normal relationship between IML and MD; and 4) … of carnitine to adriamycin-treated animals restored the normal relationship.”
“We have shown that carnitine treatment significantly decreases both acute high dose and chronic, intermittent, low dose adriamycin associated lethality in normal mice.”
“Conclusions: Carnitine levels tended to decrease after doxorubicin treatment.”
Carnitine levels and cardiac functions in children with solid malignancies receiving doxorubicin therapy“Prototypes of anticancer drugs that alter carnitine system are doxorubicin , cisplatin, carboplatin, oxaliplatin, cyclophosphamide and ifosfamide.”
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