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Possible Interaction: Carnitine and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

There was a significant increase in free and total carnitine levels after treatment for patients receiving doxorubicin than patients receiving cisplatin or ifosfamide.
Journal of pediatric hematology/oncology  •  2009  |  View Paper
In conclusion, l‐carnitine attenuated the long‐term alterations caused by doxorubicin in the germ cells and improved male reproductive capacity in adulthood.
Andrology  •  2018  |  View Paper
For heart, DOX exposure caused decline of lipid, lactate, leucine, alanine, glutamate, choline, xanthine, glycerin, carnitine , and fumarate, together with elevation of glutamine, creatine, inosine, taurine and malate.
Journal of pharmaceutical and biomedical analysis  •  2016  |  View Paper
Carnitine reduced the late testicular and spermatic damages caused by doxorubicin , probably providing a partial cytoprotection against the deleterious action of doxorubicin administration to pre‐pubertal rats.
Andrology  •  2014  |  View Paper
Taken together, these findings show that by inhibiting …‐activated acid sphingomyelinase and ceramide generation, L‐carnitine … doxorubicin‐induced apoptosis of cardiac myocytes.—Andrieu‐Abadie, N., Jaffrézou, J.‐P., Hatem, S., Laurent, G., Levade, T., …. L‐carnitine prevents doxorubicin‐induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  1999  |  View Paper
It has been found that adriamycin almost abolishes the activating effect of carnitine on state 2 respiration.
Biochimica et biophysica acta  •  1992  |  View Paper
It was concluded from this study that 1) a relationship exists … the number of IML in normal murine cardiac muscle; 2) carnitine produces an inverse … normal relationship; 3) adriamycin disturbs the normal relationship between IML and MD; and 4) … of carnitine to adriamycin-treated animals restored the normal relationship.
Journal of submicroscopic cytology  •  1982  |  View Paper
We have shown that carnitine treatment significantly decreases both acute high dose and chronic, intermittent, low dose adriamycin associated lethality in normal mice.
Biomedicine / [publiee pour l'A.A.I.C.I.G.]  •  1978  |  View Paper
Conclusions: Carnitine levels tended to decrease after doxorubicin treatment.
Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology  •  2011  |  View Paper
Prototypes of anticancer drugs that alter carnitine system are doxorubicin , cisplatin, carboplatin, oxaliplatin, cyclophosphamide and ifosfamide.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society  •  2010  |  View Paper