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Last Updated: a year ago

Possible Interaction: Carnitine and Clofibrate



Research Papers that Mention the Interaction

Hepatic carnitine palmitoyl transferase and β-oxidation activities were significantly higher in the TA and CF groups than in the control group.
British Journal of Nutrition  •  2011  |  View Paper
In conclusion, the present study shows that administration of clofibrate to rats increases carnitine absorption in small intestine which is probably due to the observed upregulation of OCTN2 mediated by activation of PPARalpha.
The absorption rate of carnitine in small intestine was markedly higher in rats treated with clofibrate than in those treated without clofibrate (P < 0.05).
This strongly suggests that PPARalpha activation in response to clofibrate treatment improves the absorption of carnitine from the diet.
Pharmacological research  •  2008  |  View Paper
It has been shown that treatment of rats with clofibrate , a synthetic agonist of PPARα, increases mRNA concentration of organic cation transporters (OCTN)-1 and -2 and concentration of carnitine in the liver.
British Journal of Nutrition  •  2007  |  View Paper
It has been shown that clofibrate treatment increases the carnitine concentration in the liver of rats.
Biochemical and biophysical research communications  •  2006  |  View Paper
A significantly smaller proportion of the hepatic pool of carnitine was released into the perfusion medium when carnitine concentration was increased by clofibrate treatment.
Hepatic carnitine concentration was increased in rats by clofibrate treatment.
We conclude that when hepatic carnitine concentration is increased by clofibrate treatment, a smaller proportion of the hepatic carnitine pool is released, but the amount of carnitine released (nmol/g liver) is not greatly different than that from control animals.
Biochemical medicine and metabolic biology  •  1992  |  View Paper
Both DHEA and clofibrate administration increased enzyme activities, immunoreactive protein, messenger RNA levels and transcription rates for the carnitine acyltransferases.
The Journal of nutrition  •  1991  |  View Paper
Our data suggest that clofibrate treatment stimulates hepatic synthesis of carnitine by increasing the availability of its precursor, trimethyllysine.
Our previous studies have shown that treatment of rats with clofibrate , a hypolipidemic drug, greatly increases the total concentration of carnitine in the liver (H. S. Paul and S. A. Adibi, J. Clin.
The American journal of physiology  •  1986  |  View Paper
Clofibrate feeding increased CoASH and carnitine tissue levels in heart and liver.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology  •  1985  |  View Paper
0.25% clofibrate in diet for 10-15 days, was found to increase carnitine 3-fold in livers of male as well as female rats.
The ratio of esterified to free carnitine in urine and serum was also increased by clofibrate.
Biochimica et biophysica acta  •  1980  |  View Paper
Clofibrate caused a 3-fold increase in hepatic carnitine levels.
Biochimica et biophysica acta  •  1978  |  View Paper