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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Carnitine
drug:
Clofibrate
Research Papers that Mention the Interaction
“ Hepatic carnitine palmitoyl transferase and β-oxidation activities were significantly higher in the TA and CF groups than in the control group.”
Tannic acid is more effective than clofibrate for the elevation of hepatic β-oxidation and the inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase and aortic lesion formation in apo E-deficient mice“In conclusion, the present study shows that administration of clofibrate to rats increases carnitine absorption in small intestine which is probably due to the observed upregulation of OCTN2 mediated by activation of PPARalpha.”
“The absorption rate of carnitine in small intestine was markedly higher in rats treated with clofibrate than in those treated without clofibrate (P < 0.05).”
“This strongly suggests that PPARalpha activation in response to clofibrate treatment improves the absorption of carnitine from the diet.”
“It has been shown that treatment of rats with clofibrate , a synthetic agonist of PPARα, increases mRNA concentration of organic cation transporters (OCTN)-1 and -2 and concentration of carnitine in the liver.”
“It has been shown that clofibrate treatment increases the carnitine concentration in the liver of rats.”
“A significantly smaller proportion of the hepatic pool of carnitine was released into the perfusion medium when carnitine concentration was increased by clofibrate treatment.”
“ Hepatic carnitine concentration was increased in rats by clofibrate treatment.”
“We conclude that when hepatic carnitine concentration is increased by clofibrate treatment, a smaller proportion of the hepatic carnitine pool is released, but the amount of carnitine released (nmol/g liver) is not greatly different than that from control animals.”
“Both DHEA and clofibrate administration increased enzyme activities, immunoreactive protein, messenger RNA levels and transcription rates for the carnitine acyltransferases.”
“Our data suggest that clofibrate treatment stimulates hepatic synthesis of carnitine by increasing the availability of its precursor, trimethyllysine.”
“Our previous studies have shown that treatment of rats with clofibrate , a hypolipidemic drug, greatly increases the total concentration of carnitine in the liver (H. S. Paul and S. A. Adibi, J. Clin.”
“ Clofibrate feeding increased CoASH and carnitine tissue levels in heart and liver.”
“0.25% clofibrate in diet for 10-15 days, was found to increase carnitine 3-fold in livers of male as well as female rats.”
“The ratio of esterified to free carnitine in urine and serum was also increased by clofibrate.”
“ Clofibrate caused a 3-fold increase in hepatic carnitine levels.”
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