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Possible Interaction: Carnitine and Clofibrate



Research Papers that Mention the Interaction

Unexpectedly, basal carnitine concentrations were found to be abnormally high in subjects receiving a combination of probucol (1 g/day) and clofibrate (2 g/day), and who also had reduced HDL-C levels.
Atherosclerosis  •  1985  |  View Paper
This strongly suggests that PPARalpha activation in response to clofibrate treatment improves the absorption of carnitine from the diet.
Pharmacological research  •  2008  |  View Paper
It has been shown that treatment of rats with clofibrate , a synthetic agonist of PPARalpha, increases mRNA concentration of organic cation transporters (OCTN)-1 and -2 and concentration of carnitine in the liver.
The British journal of nutrition  •  2007  |  View Paper
It has been shown that clofibrate treatment increases the carnitine concentration in the liver of rats.
Biochemical and biophysical research communications  •  2006  |  View Paper
A significantly smaller proportion of the hepatic pool of carnitine was released into the perfusion medium when carnitine concentration was increased by clofibrate treatment.
Hepatic carnitine concentration was increased in rats by clofibrate treatment.
We conclude that when hepatic carnitine concentration is increased by clofibrate treatment , a smaller proportion of the hepatic carnitine pool is released, but the amount of carnitine released (nmol/g liver) is not greatly different than that from control animals.
Biochemical medicine and metabolic biology  •  1992  |  View Paper
Our data suggest that clofibrate treatment stimulates hepatic synthesis of carnitine by increasing the availability of its precursor, trimethyllysine.
Our previous studies have shown that treatment of rats with clofibrate , a hypolipidemic drug, greatly increases the total concentration of carnitine in the liver (H. S. Paul and S. A. Adibi, J. Clin.
The American journal of physiology  •  1986  |  View Paper
A 4-day clofibrate treatment increases by 42% the apparent Km value of carnitine palmitoyltransferase I for palmitoyl-CoA, while the sensitivity of the enzyme to malonyl-CoA appears slightly decreased.
The data suggest that the clofibrate treatment counteracts the inhibition of activity of carnitine palmitoyltransferase I through the maintenance of mitochondrial membrane integrity.
Biochimica et biophysica acta  •  1986  |  View Paper
The ratio of esterified to free carnitine in urine and serum was also increased by clofibrate.
Biochimica et biophysica acta  •  1980  |  View Paper