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Last Updated: 2 years ago

Possible Interaction: Carnitine and Cisplatin



Research Papers that Mention the Interaction

During treatment with cisplatin , the plasma total carnitine concentration increased by approximately 30% and normalized 7 days after stopping therapy.
Similarly, urinary clearance of total carnitine was increased during therapy with cisplatin by a factor of approximately 8 and returned to normal 7 days after chemotherapy.
Urinary excretion of total carnitine increased by a factor of 10 during cisplatin administration and also normalized 7 days after cessation of chemotherapy.
European Journal of Clinical Pharmacology  •  1998  |  View Paper
Abstract Conclusion: Longitudinal assessments of carnitine and fatigue in patients with head and neck squamous cell carcinoma suggest that cisplatin damages the carnitine system in patients undergoing chemoradiotherapy and that carnitine deficiency increases fatigue.
Results: The plasma levels of total carnitine TC ), free carnitine (FC), and fatty acylcarnitine (AC) were significantly lower in mice receiving cisplatin compared with control mice.
Acta oto-laryngologica  •  2015  |  View Paper
Cisplatin did not directly inhibit the transport of carnitine by Octn2 but downregulated multiple target genes of the transcription factor peroxisome proliferator activated receptor α, including Slc22a5, in the kidney of wild-type mice that were absent in Oct1/2(−/−) mice.
We also found that cisplatin caused an increase in the urinary excretion of carnitine and acetylcarnitine in wild-type mice but not in Oct1/2(−/−) mice, suggesting that tubular transport of cisplatin is a prerequisite for this phenomenon.
Clinical Cancer Research  •  2010  |  View Paper
BACKGROUND Patients treated with cisplatin or carboplatin show increased renal excretion of carnitine.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association  •  2010  |  View Paper
On the other hand, combined treatment with cisplatin and d-carnitine induced a dramatic increase in serum alanine transaminase and gamma-glutamyl transferase, as well as progressive reduction in total carnitine and ATP content in liver tissue.
Basic & clinical pharmacology & toxicology  •  2007  |  View Paper
Background Carnitine is related to malaise, and cisplatin is associated with decreased carnitine.
BMC cancer  •  2021  |  View Paper
Carnitine or amifostine administration 30 minutes before cisplatin injection resulted a significant increase in %ID/g, 21.28±7.73 and 18.97±3.24 respectively, compared to those of cisplatin-treated rats (p<0.002).
Molecular imaging and radionuclide therapy  •  2011  |  View Paper
Prototypes of anticancer drugs that alter carnitine system are doxorubicin, cisplatin , carboplatin, oxaliplatin, cyclophosphamide and ifosfamide.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society  •  2010  |  View Paper