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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Carnitine and Choline

supplement:

Carnitine

supplement:

Choline

Research Papers that Mention the Interaction

In guinea pigs, however, choline supplementation resulted in a significantly lower urinary excretion and higher plasma total carnitine concentrations.
These … that choline supplementation results in … urinary excretion of carnitine in young adult women, that guinea pigs are a suitable animal model for studying the effect of choline supplementation on … status in humans, and that choline results in a conservation of carnitine in guinea pigs and perhaps in humans.
The Journal of nutrition  •  1995  |  View Paper
Serum and urinary carnitine increased during wk 1 in the carnitine-supplemented group and, although the introduction of choline to this group depressed serum and urinary carnitine , they remained significantly greater than control.
The Journal of nutrition  •  2003  |  View Paper
Also, the preference for choline over carnitine as an acetyl acceptor is seen to result from both electrostatic and steric blocks to carnitine binding at the active site.
The EMBO journal  •  2004  |  View Paper
The latter process is stimulated by carnitine and choline in a synergistic way in cells utilizing glucose as the main energetic substrate.
Acta neurobiologiae experimentalis  •  1996  |  View Paper
Choline , however, was incapable of reversing an inhibitory effect exerted by carnitine on acetylcholine synthesis in cortex cells from suckling animals.
Neurochemistry International  •  1995  |  View Paper