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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Carmustine
supplement:
Vitamin K
Research Papers that Mention the Interaction
“Inhibition of glutathione reductase by pretreatment of hepatocytes with 1,3-bis(2-chloroethyl)-1-nitrosourea BCNU ) greatly potentiated both GSH depletion and GSSG formation during the metabolism of low concentrations of menadione.”
Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone).“ Menadione produced a concentration-related depletion of GSH (measured as non-protein sulfhydryl content) which was potentiated markedly by BCNU.”
“ Menadione toxicity was potentiated at either concentration by BCNU based on lactate dehydrogenase leakage at 2 hr.”
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