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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Carmustine and Resveratrol



Research Papers that Mention the Interaction

Drug combination of BCNU + Resveratrol decreased the cell survival and NECTIN-4 expressions in 5-FU-R cells and NECTIN-4-over-expressed cells.
Cancer Chemotherapy and Pharmacology  •  2015  |  View Paper
Combined application of BCNU and Res caused more apoptosis in 5-FU sensitive cells in comparison to individual treatment.
Fifty percent cell death were noted in parental cells when 18 μmol/L of Res was associated with fixed concentration (20 μmol/L) of BCNU , but a much lower concentration of Res (8 μmol/L) was needed to achieve the same effect in 5-FU resistant cells.
In addition, the combined application of BCNU and Res caused a significant decrease of major DNA base excision repair components in 5-FU sensitive cells.
Increased genotoxicity and apoptosis were observed in resistant cells after combined application of BCNU and Res in comparison to untreated or parental cells.
World journal of gastroenterology  •  2013  |  View Paper