Possible Interaction: Carmustine and Glutathione

“Further inhibition of the GSH reduction however by carmustine (BCNU) resulted in an enhanced sensitivity of MCF7 to HYP-PDT.”

“Consistent with this, antioxidants such as glutathione and N-acetyl cysteine significantly reduced Carmustine mediated glioma cytotoxicity.”

“As(2)O(3) and BCNU in combination produce enhanced cytotoxicity via the depletion of reduced glutathione ( GSH ) and augmentation of reaction oxygen species (ROS) production.”

“Low concentrations of diamide plus 1,3‐bis(2 chloroethyl)‐1‐nitrosourea BCNU ) increased intracellular GSSG and decreased GSH and the GSH:GSSG ratio.”

“However, Ca2+ release was only slightly promoted by concentrations of BCNU that resulted in substantial depletion of the glutathione level.”

“S-[(2-Chloroethyl)carbamoyl]glutathione (SCCG), a compound formed during the decomposition of BCNU in the presence of GSH , induces DNA damage in a human lymphoblastoid cell line.”

“ gamma-L-glutamyl-L-cysteinylglycine (GSH) has been shown to inactivate 1,3-bis(2-chloroethyl)-1-nitrosourea ( BCNU ) and quench DNA crosslink precursors of BCNU.”

“The results … of BCNU with four … concentration of GSH for 45 min significantly inactivates BCNU, as expressed by a 32% decrease in induction of cellular DNA cross-linking, a … DNA synthesis, and a 15% increase in clonogenic survival of human brain tumor cells compared to incubates of BCNU alone.”

“Both BSO and BCNU treatments reduced cellular GSH level in AML12 and H9c2 cells, with the effect of BSO being more prominent.”

“ BCNU produced significant decreases in the GSH levels of livers of both groups, but caused no change in the GSH content of the L1210 tumor or in the lungs.”