Possible Interaction: Carmustine and Genistein

“ Genistein acts synergistically with drugs such as tamoxifen, cisplatin, 1,3-bis 2-chloroethyl-1-nitrosourea ( BCNU ), dexamethasone, daunorubicin and tiazofurin, and with bioflavonoid food supplements such as quercetin, green-tea catechins and black-tea thearubigins.”

“Conclusion: These results indicate that enistein at typical adult dietary plasma levels can significantly enhance the antiproliferative and cytotoxic action of B CNU. ”

“Presence of apoptosis, using the DNA ladder assay and laser scanning cytometry (LSC), was investigated in all cell lines at those concentrations where an enhancement of antiproliferative effect of BCNU in presence of genistein was observed.”

“Results: A 32–41% increase in monolayer growth inhibition and a 28–42% increase in colony cytotoxicity in the U87 cell line were observed when enistein (4 μM) was added to B CNU in the 0–10 μM dose range.”

“This study examined whether genistein , at a concentration typical of plasma levels following soy diet intake, in combination with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, carmustine) exhibited an additive or synergistic inhibitory effect on the growth of glioma cells.”