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Last Updated: 5 months ago

Possible Interaction: Carisoprodol and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

In addition, carisoprodol allosterically potentiated both EC20 and saturating GABA concentrations in these receptors.
With regard to α subunits, carisoprodol was most efficacious at enhancing the actions of GABA in receptors incorporating the α1 subunit.
Neuropharmacology  •  2015  |  View Paper
GABA release from each radially directed dendrite is larger for motion outward from the soma toward the dendritic tips than for motion inwards toward the soma.
The Journal of physiology  •  2016  |  View Paper
Applying GABA (1 microM-1 mM) to the soma of cultured lobster olfactory receptor neurons evokes an inward current (V(m) = -60 mV) accompanied by an increase in membrane conductance, with a half-effect of 487 microM GABA.
Applying GABA to the soma of the cells in situ reversibly suppresses the spontaneous discharge and substantially decreases the odor-evoked discharge.
Neurosignals  •  1999  |  View Paper
In the presence of high concentrations of GABA , which induced receptor desensitization, extrasynaptic receptors in outside-out patches from the soma entered long-lived closed states interrupted by infrequent clusters of openings.
The Journal of Neuroscience  •  1999  |  View Paper
In some cells, GABA and glycine elicited currents up to 300 microns from the soma.
The Journal of neuroscience : the official journal of the Society for Neuroscience  •  1994  |  View Paper
Focal applications of GABA and muscimol elicited larger currents when applied near the soma than when applied to the dendrites.(ABSTRACT TRUNCATED AT 400 WORDS)
Journal of neurophysiology  •  1990  |  View Paper
In mature tissue, both GABA and baclofen applied at the soma induce cell hyperpolarizations.
Brain research  •  1988  |  View Paper
The least effective dose was as low as 100 nM. A small insignificant response of high threshold was evoked when GABA was applied to the dendrite and soma.
Visual neuroscience  •  1988  |  View Paper
GABA … soma evoked a triphasic response when measured near the threshold voltage for action potentials: (a) the GABAhf (hyperpolarizing, fast) phase was very brief and was … reversed at -70 mV. The GABAhf response was specifically localized to the soma, whereas the apical or basilar dendrites generated predominantly GABAd responses.
The Journal of physiology  •  1988  |  View Paper
When applied close to the soma, GABA produced hyperpolarizations and depolarizations, but when GABA was applied more than 250 microns from the soma only depolarizations were recorded.
Brain Research  •  1985  |  View Paper
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