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“ Cariporide significantly reduced diastolic [ Ca ] in the cytosol of stretched myocytes.”
“The discovery that cariporide prevents the stretch-induced rise in cytosolic [ Ca ] demonstrates an important additional effect of the drug on calcium handling.”
“ Cariporide , a potent and specific inhibitor of the sodium-hydrogen exchanger, has been shown to reduce intracellular sodium and calcium concentration in the setting of myocardial ischemia and reperfusion.”