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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cardiotonic Agents
supplement:
Progestins
Research Papers that Mention the Interaction
“However, progestin addition could antagonize cardioprotective effects of estradiol.”
Estradiol inhibits LDL oxidation: do the progestins medroxyprogesterone acetate and norethisterone acetate influence this effect?“Observational data are based almost exclusively on estrogen-alone preparations, and concern has been expressed that progestogen addition may attenuate or even eliminate cardioprotection.”
“Although the role of progestin remains poorly defined, it is possible that the coadministration of progestin could counteract the cardioprotective effects of estrogen [5].”
Raloxifene hydrochloride treatment leads to better outcomes than medroxyprogesterone acetate when paired with estrogen in ovariectomized cholesterol-fed rabbits.
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