Possible Interaction: Cardiotonic Agents and Melatonin

“Vascular melatoninergic receptors have been identified and have been … vasodilator effects of melatonin.5 Other neurohormonal properties of melatonin … cardioprotective effects.5 Impaired nocturnal sympathetic suppression with sustained adrenergic activity during sleep has been reported … of melatonin may therefore contribute to the nocturnal suppression of the sympathetic nervous system.”

“Activation of SIRT6 and melatonin membrane receptors exerts cardioprotective effects while little is known about their roles during DCM.”

“These results indicate that melatonin treatment confers a dual cardio‐protective and oncostatic effect by improving mitochondrial function and cardiac function whilst simultaneously retarding tumor growth during DXR‐induced cardiotoxicity.”

“However, ICI-ERs antagonist, and melatonin , a specific inhibitor for ERα, reversed the cardioprotective effects, suggesting that E2 action was mediated through ERα.”

“Recently, several studies have shown that melatonin inhibits the stabilization of hypoxia‐inducible factors (HIFs), important signaling molecules with cardioprotective effects.”

“In conclusion, melatonin exerts cardioprotective effects and improves outcome in a model of isoproterenol‐induced heart damage.”

“Moreover, melatonin suppressed myocardial proapoptotic PKCδ expression and increased cardioprotective PKCε expression in both SHR and Wistar rats.”

“These findings add new information about the mechanisms through which melatonin physiologically modulates cardiovascular function and exerts cardioprotective effects.”

“Therefore, the results suggest that melatonin may influence the cardiac contractility after MI by regulating the expression of DHPR, RyR2, and SERCA2, and melatonin receptors, particularly MT2s, might contribute to the postinfarction cardioprotective actions of melatonin.”

“The powerful cardioprotective actions of melatonin , the chief secretory product of the pineal gland, have been attributed largely to its free radical-scavenging properties.”