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Last Updated: a year ago

Possible Interaction: Cardiotonic Agents and Melatonin

Research Papers that Mention the Interaction

Vascular melatoninergic receptors have been identified and have been … vasodilator effects of melatonin.5 Other neurohormonal properties of melatonin … cardioprotective effects.5 Impaired nocturnal sympathetic suppression with sustained adrenergic activity during sleep has been reported … of melatonin may therefore contribute to the nocturnal suppression of the sympathetic nervous system.
Hypertension Research  •  2013  |  View Paper
Activation of SIRT6 and melatonin membrane receptors exerts cardioprotective effects while little is known about their roles during DCM.
Journal of pineal research  •  2020  |  View Paper
These results indicate that melatonin treatment confers a dual cardio‐protective and oncostatic effect by improving mitochondrial function and cardiac function whilst simultaneously retarding tumor growth during DXR‐induced cardiotoxicity.
Toxicology and applied pharmacology  •  2018  |  View Paper
However, ICI-ERs antagonist, and melatonin , a specific inhibitor for ERα, reversed the cardioprotective effects, suggesting that E2 action was mediated through ERα.
Molecular and Cellular Biochemistry  •  2017  |  View Paper
Recently, several studies have shown that melatonin inhibits the stabilization of hypoxia‐inducible factors (HIFs), important signaling molecules with cardioprotective effects.
Journal of pineal research  •  2016  |  View Paper
In conclusion, melatonin exerts cardioprotective effects and improves outcome in a model of isoproterenol‐induced heart damage.
Journal of pineal research  •  2014  |  View Paper
Moreover, melatonin suppressed myocardial proapoptotic PKCδ expression and increased cardioprotective PKCε expression in both SHR and Wistar rats.
Canadian journal of physiology and pharmacology  •  2013  |  View Paper
These findings add new information about the mechanisms through which melatonin physiologically modulates cardiovascular function and exerts cardioprotective effects.
Journal of pineal research  •  2011  |  View Paper
Therefore, the results suggest that melatonin may influence the cardiac contractility after MI by regulating the expression of DHPR, RyR2, and SERCA2, and melatonin receptors, particularly MT2s, might contribute to the postinfarction cardioprotective actions of melatonin.
Journal of pineal research  •  2008  |  View Paper
The powerful cardioprotective actions of melatonin , the chief secretory product of the pineal gland, have been attributed largely to its free radical-scavenging properties.
Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners  •  2006  |  View Paper