supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago
supplement:
Cardiac Glycosides
supplement:
Progesterone
Research Papers that Mention the Interaction
“1 Certain derivatives of progesterone are potent inhibitors of high affinity, specific binding of 3H‐cardiac glycosides.”
“4 Thus, at least one hydroxylated derivative (and putative endogenous metabolite) of progesterone , mimics the cardiac effects of cardiac glycosides including enhanced contractility.”
14β‐Hydroxyprogesterone binds to the digitalis receptor, inhibits the sodium pump and enhances cardiac contractility“The stereospecific 5 beta-reduction of progesterone is a required step for cardiac glycoside biosynthesis in foxglove plants.”
Digitalis purpurea P5 beta R2, encoding steroid 5 beta-reductase, is a novel defense-related gene involved in cardenolide biosynthesis.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback