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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Cardiac Glycosides and Phenobarbital

Research Papers that Mention the Interaction

Experimental data demonstrates that cardiac glycoside digoxin enhances the anticonvulsant activity of sodium valproate, topiramate, levetiracetam, phenobarbital and clonazepam in the model of pentylenetetrazole-induced seizures, providing a clear protective effect of their sub-effective doses.
Epilepsy Research  •  2020  |  View Paper
Treatment of rats with pregnenolone-16alpha-carbonitrile (PCN) and phenobarbital increases hepatic uptake of cardiac glycosides.
The Journal of pharmacology and experimental therapeutics  •  2002  |  View Paper
The finding that Oatp2 expression increases in response to PB and PCN is consistent with our previous findings that PB and PCN enhance hepatic uptake of cardiac glycosides.
Hepatology  •  2001  |  View Paper