Possible Interaction: Cardiac Glycosides and Digoxin

“If, on the other hand, the inotropic properties and effects on atrioventricular conduction of cardiac glycosides can differ from glycoside to glycoside, the tendency to use only digoxin might limit the clinical usefulness of the cardiac glycosides.”

“All cardiac glycosides decreased [3H]‐digoxin uptake at the basal cell surface (except for 100 μm digitoxin).”

“As PGI2 and VIP may be of importance for the maintenance of a low resistance of the fetal placental vascular bed, the finding that digoxin decreases the vasodilating effects of these agents might imply effects on placental resistance of cardiac glycosides when used in late human pregnancy.”

“In the presence of digoxin , the maximum contractile responses to noradrenaline (18 microM) and potassium (127 mM) markedly increased, and the glycoside shifted the noradrenaline concentration-response curve to the left.”

“Corrected sinus nodal recovery times ranged from 240 to 2,065 msec (average 714) before digoxin and were shortened to 250 to 1,260 msec (average 565) after the glycoside.”

“… glycoside level dropped during the following … 0.3 mg of methyl-digoxin to 1.2 ng/ml (1 times 10-9 M), sodium content in the cells increased further up to …/kg and was paralleled by a decrease in potassium content from 84.6 to 82.0 meq/kg.”

“ Serum glycoside concentrations after an oral dose of digoxin were higher in dialyzed patients than in control patients, significantly so from 2 to 24 hours, reflecting the absence of the predominantly renal route of excretion of digoxin.”

“The glycoside concentration in the brain was low after a single administration of digoxin.”

“Comparison of the changes in TCH2O, V and FENa in control and digoxin-infused kidneys suggest that, although EA can potentiate the inhibitory effect of digoxin on renal sodium reabsorption, its effects are partially blocked by the cardiac glycoside.”

“A single exposure to digoxin or ouabain accounted for a more than twofold increase in the incorporation (binding) of the cardiac glycosides in the progeny generations.”