Possible Interaction: Cardiac Glycosides and Adrenergic Antagonists

“After blocking the neurogenic component of the glycoside contraction with alpha-adrenergic receptor blocking drugs or treating the animals with reserpine, ouabain-induced contractions were markedly reduced in vessels with intact endothelium.”

“Abstract Procedures which diminish adrenergic nervous activity, either by catecholamine depletion sympathectomy, adrenalectomy, inhibition of catecholamine release, or by the use of β-adrenergic-blocking agents , depress ventricular arrhythmias induced by cardiac glycosides and also increase their lethal doses.”