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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Carboxyamidotriazole and Indoximod

Research Papers that Mention the Interaction

Combining CAI with 1-MT or DMF disrupted PD-1 expression and promoted IFN-γ production in CD8+ T cells, and it also increased T lymphocyte infiltration in the tumor microenvironment, inhibited tumor growth and prolonged the life spans of tumor-bearing mice.
The combination of CAI with 1-MT or DMF greatly augmented the ability of CD8+ T cells to kill malignant cells and showed a strong anti-cancer capability that was superior to that of either of the single agents was is comparable with that of anti-PD-1 antibody.
Journal of Immunotherapy for Cancer  •  2019  |  View Paper