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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Carboxyamidotriazole
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“However, investigation of the effects of carboxyamidotriazole on mitochondrial calcium dynamics induced by carbachol, capacitative calcium entry and exogenously set calcium loads in intact and digitonin-permeabilized cells revealed that carboxyamidotriazole inhibited both calcium entry and mitochondrial calcium uptake in a time-dependent manner.”
Carboxyamidotriazole-induced inhibition of mitochondrial calcium import blocks capacitative calcium entry and cell proliferation in HEK-293 cells“ CAI (10 microM) and 2-APB (20 microM) completely blocked CCE in thapsigargin-treated Huh-7, and CAI and 2-APB inhibited cell proliferation with IC50 of 4.5 and 43 microM, respectively.”
“ CAI inhibited IP3 formation, … of the calcium signal , nitric oxide (NO) release, and proliferation induced by VEGF‐A. CAI prevented neither activation of VEGF receptor‐2 (VEGFR‐2) (KDR/…), phospholipase C‐γ, or mitogen‐activated protein kinase (MAP kinase) nor translocation of nuclear factor of activated T cells (NFAT).”
“The process of endothelial cell adhesion and spreading on extracellular matrix substrata results in an increase in intracellular calcium that can be inhibited by CAI exposure.”
“ Carboxyamidotriazole (CAI), a novel anticancer agent, inhibits calcium entry into cells.”
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