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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Carbon Monoxide
supplement:
NADH
Research Papers that Mention the Interaction
“ Carbon monoxide inhibited both NADH and NADPH-mediated lyase activities indicating that both activities are catalyzed by cytochrome P-450.”
Studies of the human testis. XX--Effect of NADH on 17 alpha-hydroxypregnene C17-20 lyase activity.“Following CO exposure in groups A and C, a definite decrease in the amplitude of the NADH response and significant increase in the number of waves of NADH was noted during induced cortical SD.”
Hyperbaric oxygenation affects rat brain function after carbon monoxide exposure.“The amplitude of the NADH oxidation waves and their integral were smaller during SD induced immediately after exposure to CO.”
“The addition of NADH caused an early, marked uptake of CO 2 , which could be completely inhibited by γ -(3,4-urelenecyclohexyl) butyric acid, a biotin antagonist.”
“ Carbon monoxide forms an intense absorption band at 450 mμ upon reduction of the microsomes by DPNH or dithionite, but no corresponding absorption band in the visible region has been found.”
“In contrast, CO decreases NADH oxidation rate and also induces release of the prosthetic groups from the native terminal reductase.”
Rubredoxin oxidase, a new flavo-hemo-protein, is the site of oxygen reduction to water by the "strict anaerobe" Desulfovibrio gigas.
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