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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Carbon Monoxide and Hydroxocobalamin

Research Papers that Mention the Interaction

OH-Cbl and CN(2)-Cbi prevented binding of the oxygen analog carbon monoxide ( CO ) to the reduced NOS1 and NOS2 heme active site.
Free radical biology & medicine  •  2009  |  View Paper
In addition to binding cyanide, hydroxocobalamin binds vasodilatory compounds hydrogen sulfide and carbon monoxide and affects nitric oxide metabolism, potentially explaining observed hypertension.
Transfusion  •  2019  |  View Paper
While treatment with hydroxocobalamin is the standard of care and has the effect of reducing concomitant CO toxicity, data indicate cyanide may also be displaced by HBO2.
Annals of plastic surgery  •  2018  |  View Paper
Because CO and CN have additive effects when both are present in the body, the prompt administration of hydroxocobalamin not only eliminates the effects of CN but also potentially attenuates its synergistic effects on CO.
Journal of burn care & research : official publication of the American Burn Association  •  2012  |  View Paper