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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Carbon Monoxide
supplement:
Hydroxocobalamin
Research Papers that Mention the Interaction
“ OH-Cbl and CN(2)-Cbi prevented binding of the oxygen analog carbon monoxide ( CO ) to the reduced NOS1 and NOS2 heme active site.”
Inhibition of nitric oxide synthase by cobalamins and cobinamides.“In addition to binding cyanide, hydroxocobalamin binds vasodilatory compounds hydrogen sulfide and carbon monoxide and affects nitric oxide metabolism, potentially explaining observed hypertension.”
“While treatment with hydroxocobalamin is the standard of care and has the effect of reducing concomitant CO toxicity, data indicate cyanide may also be displaced by HBO2.”
“Because CO and CN have additive effects when both are present in the body, the prompt administration of hydroxocobalamin not only eliminates the effects of CN but also potentially attenuates its synergistic effects on CO.”
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