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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Carbon Monoxide
supplement:
Homocysteine
Research Papers that Mention the Interaction
“Instead, CO prevented X-box binding protein 1 expression and activating transcription factor 6 cleavage induced by ER-stress inducers such as thapsigargin, tunicamycin and homocysteine.”
Carbon Monoxide Induces Heme Oxygenase-1 via Activation of Protein Kinase R–Like Endoplasmic Reticulum Kinase and Inhibits Endothelial Cell Apoptosis Triggered by Endoplasmic Reticulum Stress“Furthermore, inhibition by CO is competitive with respect to homocysteine , providing the first indication that the homocysteine binding site is in the proximity of heme.”
“The Hcy level showed a significant negative correlation with NOS activity (rA = -0.89, rB = -0.76, rc = -0.91, rD = -0.91) and CO content (TA = -0.82, r, = -0.77, rc = -0.93, rD = -0.81).”
[Correlation of homocysteine in plasma with NOS and endogenous CO in the penile corpus cavernosum of type 2 diabetic rats].“Estimates of the dietary Co concentration required to minimise homocysteine were 161 (se 10) μg/kg DM.”
“The dietary Co was inversely correlated with the plasma concentrations of homocysteine and MMA.”
“Furthermore, inhibition by CO is competitive with respect to homocysteine , providing the first indication that the homocysteine binding site is in the proximity of heme.”
Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites
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