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Last Updated: a year ago

Possible Interaction: Carbon Monoxide and Histidine

supplement:

Histidine

Research Papers that Mention the Interaction

Other ligands such as CO , or CN for the ferric form, show a decreased affinity, since only the competition with the E7 histidine , but not the stabilizing H‐bond, plays a role.
IUBMB life  •  2004  |  View Paper
The distal histidine in this subunit inhibits the bimolecular rate of binding of both O2 and CO , sterically hinders bound CO and methyl isocyanide, and stabilizes bound O2 by hydrogen bonding.
The Journal of biological chemistry  •  1989  |  View Paper
Oxygen, nitric oxide, or carbon monoxide can displace the distal histidine which, in ferrous Ngb as well as in ferric Ngb, is bound to the iron, yielding a reversible adduct.
Biophysical journal  •  2007  |  View Paper
Whereas the hydrogen bonding network and packing contacts formed in the dimeric interface of lamprey hemoglobin are largely unaffected by ligand binding, the binding of carbon monoxide induces the distal histidine to swing to positions that would preclude the formation of a stabilizing hydrogen bond with the bound ligand.
The Journal of Biological Chemistry  •  2001  |  View Paper
However, all such structures lead to unfavourable interactions between the histidine and CO , and to νCO frequencies higher than those observed experimentally.
JBIC Journal of Biological Inorganic Chemistry  •  1999  |  View Paper
These results suggest that intracellular histidine , most likely in the vacuole, diminishes the pH-dependent toxicity of Cu, Co , and Ni.
Journal of bacteriology  •  1999  |  View Paper