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“Other ligands such as CO , or CN for the ferric form, show a decreased affinity, since only the competition with the E7 histidine , but not the stabilizing H‐bond, plays a role.”
“The distal histidine in this subunit inhibits the bimolecular rate of binding of both O2 and CO , sterically hinders bound CO and methyl isocyanide, and stabilizes bound O2 by hydrogen bonding.”
The Journal of biological chemistry • 1989 | View Paper
“Oxygen, nitric oxide, or carbon monoxide can displace the distal histidine which, in ferrous Ngb as well as in ferric Ngb, is bound to the iron, yielding a reversible adduct.”
“Whereas the hydrogen bonding network and packing contacts formed in the dimeric interface of lamprey hemoglobin are largely unaffected by ligand binding, the binding of carbon monoxide induces the distal histidine to swing to positions that would preclude the formation of a stabilizing hydrogen bond with the bound ligand.”
The Journal of Biological Chemistry • 2001 | View Paper
“However, all such structures lead to unfavourable interactions between the histidine and CO , and to νCO frequencies higher than those observed experimentally.”